Notch-regulated Ankyrin Repeat Protein Is Overexpressed in Different Subtypes of Breast Cancer
نویسندگان
چکیده
Introduction: Breast cancer (BC) is a highly heterogeneous disease that has been classified into several subtypes at the molecular level, each with distinct outcome. Recently, Notch-regulated ankyrin-repeat protein (NRARP), gene expressed followed by Notch signal activation, attracted interest due to its aberrant expression in different types of cancer. Accordingly, this study evaluated levels NRARP BC. Methods: The MCF-7, SKBR3, MDA-MB-468, and MDA-MB-231 human BC cell lines, which represent luminal, epidermal growth factor receptor 2 (HER2) overexpression, basal A, B subtypes, respectively, as well MCF-10A normal breast epithelial for comparison, were selected grown appropriate medium. relative lines was then determined using quantitative real-time polymerase chain reaction (qRT-PCR). Results: results qRT-PCR demonstrated level all significantly higher than cells (P<0.05). However, significance more noteworthy HER2-overexpressing, A (7.72, 5.81, 4.6 folds, respectively). Conclusion: potential target further interventional studies abnormal
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ژورنال
عنوان ژورنال: International journal of basic science in medicine
سال: 2022
ISSN: ['2476-664X']
DOI: https://doi.org/10.34172/ijbsm.2022.24